Serena Williams Stars in Ro’s First-Ever Super Bowl Ad
Ro, the direct-to-patient healthcare company, has partnered with Young Hero to launch its first-ever Super Bowl commercial starring its GLP-1 patient ambassador, Serena Williams.
The commercial marks the launch of 'Healthier on Ro,' a new national campaign spanning TV, digital and out-of-home, designed to highlight the benefits of GLP-1s, including weight loss and other health biomarkers.
In the Super Bowl spot, Serena shares the health improvements she’s experiencing on GLP-1s, including losing 34 pounds in a year and, as a result, reduced knee joint stress and steady blood sugar.
"Our Super Bowl ad and the whole 'Healthier on Ro' campaign looks beyond the scale to focus on how Serena and our other patient ambassadors feel healthier and supported on Ro," said Saman Rahmanian, co-founder and chief product officer of Ro, speaking with LBB. "We want to make clear to viewers that we’re here every step of their health journey, from getting started to achieving their goals."
The Ro team knew Serena would be the ideal Super Bowl story ever since they partnered in August 2025. "We've been excited by the response to the initial campaign, and how Serena inspired people to take action about their health. With the Super Bowl ad, we wanted to build on the success of the first campaign while highlighting the amazing health benefits she’s experiencing on a GLP-1."
“I feel better now than I have in years,” said Serena Williams, in a brand statement. “For me, this journey has been about feeling strong, energised and healthy in my body; I feel like myself again. Being on Ro helped me focus on my health in a way that actually worked for me, and I’m excited to share how great I feel with millions of people during the Super Bowl.”
The campaign launches at a moment when GLP-1 medications are more accessible to more eligible people than ever. Serena's health journey across the campaign is helping Ro reach new audiences by normalising the process and empowering people to seek GLP-1 treatment.
"There is no one with more willpower and self-discipline than Serena Williams, which is why she’s the perfect person to help people see that GLP-1s are not a shortcut," said Zach Reitano, co-founder and CEO of Ro. "Serena’s journey on Ro has been an inspiration to millions of people. We’re excited to continue to work with her to share how Ro and GLP-1s have helped achieve her health goals. This is just the beginning.”
The 'Healthier on Ro' campaign will also feature fellow Ro GLP-1 patient ambassador Charles Barkley and other real Ro patients who have lost weight and improved their health. These patients include:
- Hannah Nylander-Asplin, Minneapolis-based runner who lost 75 pounds over a year and a half and gained enough energy and mobility to go from running a mile to completing a marathon.
- Deanna and Mitchell Taylor, Atlanta-based husband and wife who together lost 41 pounds on Ro and have increased energy and mobility to keep up with their young kids.
- Greg Olson, Colorado-based cyclist who lost 78 pounds in nine months and saw improvements in his confidence on Ro.
With these different stories set to debut in Ro's marketing soon, Saman tells LBB that the brand's Super Bowl spot with Serena Williams is just the opening chapter in its fight to expand access to GLP-1 treatment through personalised, online care. "Even though all of these patients have different lives and starting points, our campaign tells the same underlying story, highlighting how, after starting on a GLP-1, our patients feel healthier and have the support they need on Ro."
The campaign will debut during the Super Bowl LX NBC broadcast on February 8th and be supported by a national advertising strategy spanning linear and broadcast TV, paid social, and out-of-home takeovers launching in cities across the US.
Keep up with everything Super Bowl LX here.
